Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and copyright in Mice: Influence of the Novelty-Seeking Trait

Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and copyright in Mice: Influence of the Novelty-Seeking Trait

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Adolescent exposure to cannabinoids enhances the behavioural effects of copyright, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug.Our aim was to evaluate the influence animed aniflex complete of novelty-seeking on the effects of adolescent cannabinoid exposure.Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test.First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.

05 and 0.075 mg/kg, i.p.) in HNS and LNS mice.

Then, HNS and LNS mice were pretreated i.p.with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently conditioned with WIN 55212-2 (0.

05 mg/kg, i.p.) or merrick backcountry wet cat food copyright (1 or 6 mg/kg, i.p.

).Only HNS mice conditioned with the 0.075 mg/kg dose acquired CPP with WIN 55212-2.Adolescent exposure to this cannabinoid agonist increased the rewarding effects of 1 mg/kg of copyright in both HNS and LNS mice, and in HNS mice it also increased the reinstating effect of a low dose of copyright.

Our results endorse a role for individual differences such as a higher propensity for sensation-seeking in the development of addiction.